Carla Gugino was born on Aug. 29, 1971, in Sarasota Fla., to orthodontist Carl and Susan Gugino. Her parents divorced whan she was 2 years old and she was shuttled between them. When she was 4, her mother moved with her to Paradise, Calif. As a teen, she worked as a model and made enough to support herself and was emancipated from her parents (with their consent) at age 16.
In 1988, she made her TV debut in a guest role on Who's the Boss? and then Good Morning, Miss Bliss. Her movie debut came in 1989's Troop Beverly Hills, followed 1990's Welcome Home, Roxy Carmichael.
- Troop Beverly Hills (1989)
- Quantum Leap -- "Ghost Ship" (1992)
- This Boy's Life (1993)
- Spy Kids (2001)
- Spy Kids 2: The Island of Lost Dreams (2002)
- Spy Kids 3-D: Game Over (2003)
- Karen Sisco (2003-'04)
- Sin City (2005)
- Threshold (2005-'06)
- Night at the Museum (2006)
- Entourage (2007-'10)
- Watchmen (2009)
- Californication (2010)
- Sucker Punch (2011)
- Political Animals (2012)
- Carla appeared in a 2006 Off-Broadway revival of Tennessee Williams' Suddenly Las Summer with Blythe Danner.
- She co-produced the 1998 film Judas Kiss.
- She sang "Love is the Drug" alongside Oscar Isaac for the movie's soundtrack.
- 2007 Capri Italian-America Award
Carla is in a committed relationship with Sebastian Gutierrez, a Venezuelan director, producer and screenwriter.
- Carla is the niece of former Let's Make a Deal spokesmodel Carol Merrill.
- The TV series Karen Sisco is a sequel of sorts to Elmore Leonard's 1998 movie Out of Sight , in which Jennifer Lopez played U,S, Marshall Karen Sisco.
- In Welcome Home, Roxy Carmichael, Carla played the young version of Roxy.
- Carla and Sebastian met as actors on the 1996 film Wedding Bell Blues.